Bosentan API

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Bosentan API Specification

Chemical Name
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide

Payment Terms
Paypal, Western Union, Telegraphic Transfer (T/T), Cash in Advance (CID), Cash Advance (CA)

Packaging Details
25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.

Main Export Market(s)
Australia, North America, Eastern Europe, Western Europe, Middle East, Central America, South America, Asia, Africa

Bosentan is a mixed endothelin receptor antagonist which is used as a vasodilator. Bosentan is an inhibitor of ETAR and ETBR.

Specification:

Analysis Test	Specification	Result
Description	white crystalline powder	Conforms
Solubility	Easily soluble in water, unsoluble in ethanol	Conforms
PH	6.0-7.5	6.9
Solution clarity and color	solution should be clear and colorless	Conforms
Related substances	CMP 0.3% Simple impurity Total other impurity	0.01% 0.03% 0.10%
Chloride	0.05%	Conforms
Ammonium	0.05%	Conforms
Fe	0.01%	Conforms
Phosphate	0.1%	Conforms
Loss on drying	<6.0%	1.3%
Heavy metals	0.002%	Conforms
Arsenide	0.0001%	Conforms
Bacterial Endotoxins	0.3EU/mg	Conforms
Microbial Limit	Conforms	Conforms
Assay(on dried basis)	>98.0%	98.8%

Packaging details:

Packaging details:	25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.
Storage:	Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat
Shelf Life:	5 years if sealed and store away from direct sun light.