About Amiloride HCl
Amilorideis apotassium-sparing diuretic,used in the management ofhypertensionandcongestive heart failure. Amiloride was also tested as treatment ofcystic fibrosis.
Mechanism of Action:
Amiloride works by directly blocking theepithelial sodium channel(ENaC) thereby inhibitingsodiumreabsorption in the latedistal convoluted tubules, connecting tubules, and collecting ducts in thekidneys(this mechanism is the same fortriamterene).This promotes the loss of sodium and water from the body, but without depletingpotassium. The drug is often used in conjunction withthiazide(e.g.co-amilozide) orloop diuretics(e.g.co-amilofruse). Due to its potassium-sparing capacities,hyperkalemia(high blood potassium levels) is occasionally observed in patients taking amiloride. The risk is high in concurrent use ofACE inhibitorsorspironolactone.
- Appearance-Yellow or yellow green crystalline powder
- CAS Registry Number-2016-88-8
- Molecular Weight-266.09
- Molecular Formula- C6H8ClN7O.HCl
Packaging details:
| Packaging details: | 25KG/Drum with double plastic bag inside; Aluminium foil bag with plastic bag inside and carton box outside for small quantity |
| Storage: | Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
| Shelf Life: | 5 years if sealed and store away from direct sun light. |
Exceptional Purity and StabilityAmiloride HCl is manufactured to stringent quality standards, offering 99% purity for pharmaceutical applications. Its robust crystalline form ensures stability and longevity, supporting both short-term and long-term production needs. The chemical's five-year shelf life, provided it's kept away from moisture, gives industries dependable performance.
Versatile Pharmaceutical ApplicationsAs a crucial intermediate in pharmaceutical synthesis, Amiloride HCl is utilized in the formulation of various medicines. Its unique properties make it highly compatible for research, development, and commercial health care solutions. This ensures its relevance across a broad spectrum of pharmaceutical products.
FAQ's of Amiloride HCl:
Q: How should Amiloride HCl powder be stored to maintain its quality?
A: Amiloride HCl powder must be kept away from moisture and in a dry, airtight container at room temperature. Proper storage ensures the integrity of the crystalline form and maintains its 99% purity for the duration of its five-year shelf life.
Q: What are the primary uses of Amiloride HCl in pharmaceuticals?
A: Amiloride HCl is primarily used as a pharmaceutical intermediate in the synthesis of various medications. Its role is crucial in developing effective health care products due to its stability, purity, and compatibility within diverse chemical processes.
Q: When should Amiloride HCl be sourced during pharmaceutical production?
A: Amiloride HCl should be procured during the initial stages of pharmaceutical formulation, where high-purity intermediates are essential for consistent outcomes in final medicine production. Its long shelf life allows for advance bulk purchasing for ongoing operations.
Q: Where is Amiloride HCl available for bulk supply?
A: Amiloride HCl is available from reputed distributors, exporters, manufacturers, suppliers, traders, and wholesalers throughout India. Bulk quantities can be sourced reliably for pharmaceutical and health care industries.
Q: What is the process for safely handling Amiloride HCl powder?
A: Amiloride HCl should be handled with care using appropriate personal protective equipment, such as gloves, lab coats, and eye protection, in well-ventilated conditions. Preventing exposure to moisture is critical to maintaining its efficacy and chemical stability.
Q: What are the key benefits of using Amiloride HCl as a pharmaceutical intermediate?
A: Key benefits include its remarkable 99% purity, extended five-year shelf life, and reliable performance in pharmaceutical formulations. These attributes help ensure consistent quality and safety in the development of health care products.