Captopril (rINN) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process.
Specification:
Product name | Captopril |
Appearance | White or almost white crystalline powder |
Solubility | Freely soluble in water,in methylene chloride and in methanol.
It dissolves in dilute solutions of alkali hydroxides. |
Identification | Ir spectrum conformod tothat of captopril crs |
Appearance of solutions | Clear and colorless |
Melting range | Between 104 and 110 |
Specific optical rotation | -125 to -130 |
Related substance
Ampa Captopril disulfide Single unknown impurity Tctal unknown impurities |
Not more than 0.2% Not more than 1.0% Not more than 0.2% Not more than 0.5% |
Heavy metals | Not more than 0.003% |
Loss on drying | Not more than 1.0% |
Sulphated ash | Not more than 0.2% |
Assay | 97.5%~102.0% calculated on anhydrous basis |
Packaging details:
Packaging details: | 25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum. |
Storage: | Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
Shelf Life: | 5 years if sealed and store away from direct sun light. |
WHITE SWAN PHARMACEUTICAL
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