Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterases type 5 (PDE5). The physiologic mechanism of erection of the penis involves release of Nitric Oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzymes gyanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of Nitric Oxide (NO) by inhibiting phosphodiesterases type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil causes increase level of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

Price:
Price 0.8 USD ($) / Box
Minimum Order Quantity : 1000 Boxes
Physical Form : Tablets
Ingredients : Sildenafil 100 mg
Storage Instructions : Store In a Cool & Dry Place
Drug Type : General Medicines
Price 0.70-0.80 USD ($) / Unit
Minimum Order Quantity : 1000 Boxes
Physical Form : Tablets
Ingredients : Tadalafil 40mg
Storage Instructions : Store In a Cool & Dry Place
Drug Type : Generic Drugs
Price 15-18 USD ($)
Minimum Order Quantity : As required by client. Unit
Physical Form : Liquid
Ingredients : Aminophylline 250/500mg
Storage Instructions : Store in Cool & Dry Place
Drug Type : Injection
Price 5.0 USD ($) / UNITS
Minimum Order Quantity : 1000
Physical Form : Tablets
Ingredients : Tadalafil