Buclizine API

Buclizine API About

Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.

Properties	STANDARD
Condition of water solution	Passes test
Cd<%	0.0001
Lead(Pb)%max	0.001
Arsenic(As)%max	0.0001
Hg<%	0.0001
PH	3.2-3.8
Loss on drying %max	0.5
Specific Rotation	+17.5 - +18.5
Melting Point	110-120
E. Coli	Negative
Salmonelia	Negative
Coliforms	Negative
Yeast &Mould	<100g
Total plate count	<3000g
Appearance	White crystalline powder

 Packaging details:

 

Packaging details:	25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.
Storage:	Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat
Shelf Life:	5 years if sealed and store away from direct sun light.

Composition and Physical Properties

Buclizine Hcl is offered as a white crystalline powder characterized by a melting point range of 105-110C and a boiling point of 218C. The substance exhibits low solubility (2.46e-04 g/L) and complies with strict standards for heavy metals and moisture content. These properties underscore its suitability for pharmaceutical applications.


Proper Handling and Storage

To guarantee maximum shelf life and stability, Buclizine Hcl should be stored at room temperature in a tightly sealed container, away from moisture. Adhering to proper handling guidelines ensures the substance remains within specified limits for loss on drying and heavy metal content throughout its 5-year shelf life.


Therapeutic Use and Application

As an antiemetic, Buclizine Hcl is utilized in pharmaceutical formulations to prevent and manage nausea and vomiting. Its efficacy and established safety profile make it a preferred choice among healthcare providers and pharmaceutical manufacturers alike.