Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterases type 5 (PDE5). The physiologic mechanism of erection of the penis involves release of Nitric Oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzymes gyanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of Nitric Oxide (NO) by inhibiting phosphodiesterases type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil causes increase level of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

Price:
Price 5.0 USD ($) / Unit
Minimum Order Quantity : 1000 Units, Unit
Ingredients : Sildenafil Citrate 100mg
Physical Form : Tablets
Dosage : 50mg or as prescribed by physician
Drug Type : Other, Allopathic
Price 10.0 USD ($) / UNITS
Minimum Order Quantity : 1000
Ingredients : Sildenafil 100mg
Physical Form : Tablets
Dosage : As directed by physician, typically one tablet before sexual activity
Drug Type : Other, Allopathic
Price 13.5 USD ($) / Box
Minimum Order Quantity : 1000 Boxes
Ingredients : Ivermectin 3/6/12 mg
Physical Form : Tablets
Dosage : As Directed By Physician
Drug Type : General Medicines
Price 0.70-0.80 USD ($) / Unit
Minimum Order Quantity : 1000 Boxes
Ingredients : Tadalafil 40mg
Physical Form : Tablets
Dosage : As Directed By Physician
Drug Type : Generic Drugs