Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterases type 5 (PDE5). The physiologic mechanism of erection of the penis involves release of Nitric Oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzymes gyanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of Nitric Oxide (NO) by inhibiting phosphodiesterases type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil causes increase level of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

Price:
Price 5.0 USD ($) / Strip
Minimum Order Quantity : 1000 Strips, Strip
Storage Instructions : Store in a cool, dry place, away from direct sunlight
Dosage : As directed by physician
Dosage Guidelines : Take before sexual activity or as prescribed
Physical Form : Tablets
Price 10.0 USD ($) / UNITS
Minimum Order Quantity : 1000
Storage Instructions : Store in a cool, dry place away from direct sunlight
Dosage : As directed by physician, typically one tablet before sexual activity
Dosage Guidelines : Take one tablet with water 3060 minutes before intercourse
Physical Form : Tablets
Price 12.0 USD ($) / Unit
Minimum Order Quantity : 1000 Units
Storage Instructions : Store In A Cool & Dry Place
Dosage : As Directed By Physician
Dosage Guidelines : As Directed By Physician
Physical Form : Liquid
Price 0.15 USD ($) / Box
Minimum Order Quantity : 1000 Boxes
Storage Instructions : Store In a Cool & Dry Place
Dosage : As Directed By Physician
Dosage Guidelines : As Directed By Physician
Physical Form : Tablets