AmilorideÂ is aÂ potassium-sparing diuretic,Â used in the management ofÂ hypertensionÂ andcongestive heart failure. Amiloride was also tested as treatment ofcystic fibrosis.
Mechanism of Action:
Amiloride works by directly blocking theÂ epithelial sodium channel(ENaC) thereby inhibitingÂ sodiumÂ reabsorption in the lateÂ distal convoluted tubules, connecting tubules, and collecting ducts in thekidneysÂ (this mechanism is the same forÂ triamterene).This promotes the loss of sodium and water from the body, but without depletingpotassium. The drug is often used in conjunction withÂ thiazideÂ (e.g.co-amilozide) orÂ loop diureticsÂ (e.g.Â co-amilofruse). Due to its potassium-sparing capacities,Â hyperkalemiaÂ (high blood potassium levels) is occasionally observed in patients taking amiloride. The risk is high in concurrent use ofÂ ACE inhibitorsÂ orÂ spironolactone.
- Â AppearanceÂ -Yellow or yellow green crystalline powder
- CAS Registry NumberÂ -2016-88-8
- Molecular WeightÂ -266.09
- Molecular FormulaÂ - C6H8ClN7O.HCl
||25KG/Drum with double plastic bag inside;Â Aluminium foil bag with plastic bagÂ inside and carton box outside for small quantity
||Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat
||5 years if sealed and store away from direct sun light.